Discovering an abnormal IGF-1 value on a blood test can raise questions. This indicator, although complex, provides valuable information about the body’s hormonal balance. Understanding its role and the significance of its variations is an important step for informed medical monitoring. This article aims to clarify what IGF-1 is, how to interpret its results, and what its health implications are, in a factual and accessible manner.

What is IGF-1?

IGF-1, or “Insulin-like Growth Factor 1,” is a protein that plays a central role in the body. The liver is the main producer of this hormone under the impetus of growth hormone (GH), itself secreted by the pituitary gland, a small gland located at the base of the brain.

IGF-1 acts as a biological messenger. It circulates in the blood and binds to receptors on the surface of cells in many tissues. This action triggers signals that promote cell growth and multiplication. In practice, it is the primary mediator of the effects of growth hormone.

Measuring IGF-1 is a reliable tool for doctors. Unlike growth hormone, whose level varies greatly throughout the day, IGF-1 levels remain stable. A blood test for this marker therefore provides a representative overview of the average growth hormone production over several days. This makes it a marker of choice for evaluating somatotropic function, particularly in the investigation of growth disorders or hormonal imbalances.

Why Monitor IGF-1 Levels?

This blood level is much more than just a number. It is an indicator of overall health, interconnected with many vital processes. A value outside the normal range can, if it persists, be a sign of an underlying condition or influence various body systems.

An imbalance in the level can have consequences on:

• Sugar and energy metabolism.
• Bone density and bone health.
• Muscle mass and function.
• Tissue regeneration.
• The cardiovascular system.

For example, unexplained chronic fatigue in an adult can sometimes prompt the prescription of an IGF-1 test. If the result reveals a very low level, it may point to a growth hormone deficiency and allow for appropriate follow-up. Understanding the usefulness of this marker helps to better communicate with your doctor and participate actively in your care journey.

How to Interpret an IGF-1 Level Analysis?

Interpreting an analysis result for this blood marker requires taking into account several elements.

Reading the Results Sheet

On your laboratory report, the result is often presented in a table:

Parameter	Your Result	Reference Values	Unit
IGF-1	XXX	[YYY – ZZZ]	ng/mL

The most common unit is nanograms per milliliter (ng/mL), but nmol/L can also be used. Laboratories often indicate an abnormal value with a color (red) or a symbol (arrow up or down).

Understanding Reference Values

A crucial point is that normal IGF-1 values are not universal. They depend heavily on two main factors:

1. Age: The level is high during childhood and adolescence, peaks around puberty, then gradually and naturally decreases throughout adult life.
2. Sex: Differences also exist between men and women.

Each laboratory therefore establishes its own reference intervals based on a healthy population and according to the analytical method it uses. The individual must therefore always compare their result to the reference values that the laboratory provides for their own age range and sex.

Conditions Associated with Abnormal Levels

A significant and persistent variation in IGF-1 levels can be linked to different medical conditions.

Causes of High Levels

An abnormal elevation in levels is most often associated with overproduction of growth hormone.

• Acromegaly: This rare condition is usually caused by a benign tumor of the pituitary gland that secretes excess growth hormone. This overproduction continuously stimulates the liver, which then produces too much IGF-1. Symptoms include enlargement of the hands and feet, changes in facial features, and metabolic complications. Diagnosis is confirmed by specific hormonal tests and a pituitary MRI.
• Precocious Puberty: Premature activation of the growth hormone axis can lead to an elevation in IGF-1.
• Other situations: Less commonly, certain states of hyperinsulinism (excess insulin) can also stimulate IGF-1 production.

Causes of Low Levels

An IGF-1 deficiency can have multiple origins.

• Growth Hormone Deficiency: Whether congenital or acquired (following a tumor, trauma, radiation therapy), a lack of growth hormone is the most direct cause. In children, it manifests as growth retardation. In adults, symptoms are varied: fatigue, decreased muscle mass, increased fat mass.
• Malnutrition: Insufficient protein and calorie intake forces the liver to reduce its IGF-1 production. This is a mechanism of the body’s adaptation to undernutrition.
• Liver Failure: The liver being the main site of production, a severe liver disease (such as cirrhosis) impairs its ability to synthesize IGF-1.
• Hypothyroidism: A deficiency in thyroid hormones can also disrupt the regulation and production of this blood marker.

Advice and Follow-up for Abnormal Levels

Managing an abnormal level depends on its significance and the identified cause. Only a doctor can establish an appropriate follow-up strategy.

Frequency of Medical Follow-up

As an indication, monitoring can be:

• Annually for a slight and isolated variation.
• Semi-annually or quarterly for a more significant abnormality or as part of the follow-up of a known condition, depending on medical advice.

Influence of Lifestyle

Certain aspects of lifestyle can modulate hormonal balance, including the GH/IGF-1 axis.

• Diet: Sufficient intake of quality protein is necessary for IGF-1 production. Conversely, very restrictive diets can decrease it.
• Physical Activity: Exercise, particularly resistance training (weightlifting), can moderately stimulate the production of this blood marker. Moderate endurance contributes to overall hormonal balance.
• Sleep: Quality and sufficient sleep are essential for optimal growth hormone secretion, which primarily occurs at night.
• Stress Management: Chronic stress can disrupt many hormonal axes.

It is important to note that these adaptations cannot replace medical treatment in the case of a confirmed condition.

When to See a Specialist?

It is recommended to consult an endocrinologist if:

• The IGF-1 level is very far from the reference values.
• Symptoms suggestive of a hormonal disorder are present.
• The anomaly persists over several successive checks.

Simple monitoring by the primary care physician is often sufficient for slight variations without associated symptoms.

Frequently Asked Questions

Do I Need to Fast for an IGF-1 Blood Test?

No, strict fasting is generally not necessary. IGF-1 levels are relatively stable and minimally influenced by recent food intake, which differentiates it from growth hormone. The sample can be taken at any time of the day.

Do Certain Medications Affect IGF-1 Levels?

Yes, several treatments can influence the results. High-dose corticosteroids taken over a long period tend to decrease IGF-1 levels. Some oral contraceptives can slightly increase it. It is therefore crucial to inform your doctor of all current medications when interpreting the results.

What is the Link Between IGF-1 and Cardiovascular Risk?

Research suggests a “U-shaped curve” relationship. This means that very low levels, as well as very high levels of IGF-1, are associated with an increased risk of cardiovascular disease. Balanced levels, within the normal range for age, appear to be protective for the heart and blood vessels.

Is IGF-1 Only Produced by the Liver?

While the liver is the primary producer of circulating IGF-1 in the blood, many other tissues (bones, muscles, etc.) can produce it locally. This local IGF-1 acts directly on the spot for cell growth and repair, without entering the general bloodstream.

Additional resources

• To deepen your knowledge of this blood marker, click here.
• To extend your knowledge and decipher other markers, more articles are available here.

Confused by your blood test results?

Get instant clarity. AI DiagMe interprets your blood test results online in minutes. Our secure platform translates complex medical data into an easy-to-understand report. Take control of your health today. Visit aidiagme.com to get your personalized insights now.